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: ALFA 28A Little piggies : TOES 29A Dadaism, its said : ANTI-ART 31A Naught : NIL 32A Wild cats : YOUTHFUL INDISCRETIONS (Wild oats) 36A Animated figure : TOON 37A Extraterrestrial British TV villain that debuted in 1963 : DALEK 38A Laura seen in Big Little Lies : DERN 39A King ___ : LEAR 40A Greatly admires : REVERES 42A Table salt, in a lab : NACL 44A Fans buzz : WHIRR 46A Restaurant prearrangement, in brief : RES 47A Whats the ___? : DIF 49A Gaping gap : CHASM 52A Replay reviewer : REF 53A Days in Spain : DIAS 55A A string player plays the strings with it : BOW 58A Try intermittent fasting, perhaps : DIET 60A P.G.A

Going back to the 1930s, tobacco companies promoted their products as healthy

PMID 2784947

twice as likely to suffer from depression