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Although interactions between pharmacokinetic drugs and tobacco smoke are primarily attributed to PAHs rather than nicotine, the latter is significantly involved in pharmacodynamic interactions through the activation of the sympathetic nervous system ( Beyond PAHs and nicotine, other substances such as acetone, pyridine, heavy metals, benzene, and CO in tobacco smoke may also interact with hepatic enzymes, albeit their impact is considered less significant (Kroon, 2007)

The CDC warns that preventing teens from using e-cigarettes is vital to preventing future teen tobacco use of any kind

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