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The estimated global acute and chronic deaths attributable to the 2023 Canadian wildfires varied by a factor of 4 (1,3005,400) and 5 (31,000152,000), respectively, when different exposureresponse functions were used (Supplementary Tables 7 and 8

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In contrast, the heterogeneity in the moderate to high-dose group (10 cigarettes/day, I 2 =33.5%) may reflect genetic susceptibility or modification by confounding factors like alcohol consumption