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Nevertheless, complement activation in the pathogenesis of cardiovascular disease is well described, from the earliest signs of endothelial dysfunction, followed by progression to the formation of atherosclerotic plaques and vascular thrombus, with accompanied proinflammatory and procoagulant changes [63, 64]

Regulation: Require FDA approval through the Premarket Approval (PMA) process, where manufacturers must provide valid scientific evidence of the safety and effectiveness of the devices for their intended uses

Participants noted that smoking often serves as a coping mechanism or social activity in the absence of other fulfilling options

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