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We have shown that cigarette smoke extract reduces, in a dose- and time-dependent manner, sperm motility and the percentage of spermatozoa with normal mitochondrial function, whereas it increases the percentage of spermatozoa with abnormal chromatin and fragmented DNA (Calogero et al., In particular, the effects of nicotine (NIC), an alkaloid present in the tobacco plant and the main constituent of cigarette smoke, on sperm parameters, have been studied, showing that it alters sperm parameters (Pacifici et al., 1995

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10.1016/j.nut.2016.07.018 9 BonoraM.GiorgiC.PintonP