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Odds Ratio for Irritable Bowel Syndrome for various independent variables Variable P-value c Crude OR (95% CI) Adjusted OR (95% CI) Smoking Status Yes No 0.015 0.33 (0.14-0.81) 3.00 (1.23-7.30) 0.33 (0.13-0.80) 3.03 (1.24-7.44) Duration of Smoking* Less than 10 pack-years Greater than 10 pack-years 0.450 0.450 1.91 (0.36-10.22) 0.52 (0.10-2.80) 1.94 (0.39-10.25) 0.55 (0.13-2.83) Food Groups Meat products Dairy products Fried Food Spicy Food 0.344 0.974 0.103 0.162 0.61 (0.21-1.71) 0.98 (0.21-4.44) 0.51 (0.23-1.15) 0.57 (0.26-1.25) 0.57 (0.17-1.80) 1.13 (0.23-5.64) 0.96 (0.31-2.93) 0.72 (0.25-2.07) Gender Male Female 0.000 0.28 (0.13-0.64) 3.57 (1.56-7.69) 0.26 (0.10-0.69) 3.55 (1.54-7.71) Age (years) 0.982 1.00 (0.97-1.03) 1.03 (0.99-1.07) BMI (kg/m 2 ) 0.163 0.94 (0.85-1.03) 0.95 (0.87-1.04) *One pack year= 20 cigarettes (1 pack) smoked per day for one year

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Smoking is the biggest cause of preventable deaths in England, accounting for more than 80,000 deaths each year