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In the 1950s, cutting-edge X-ray diffraction studies along with intense scientific interactions of James Watson, Rosalind Franklin and Donald Caspar revealed the first major clues of the helical organization of the TMV nucleoprotein particles (for a thorough historic overview see [28])

115 In patients who have had previous chemotherapy, who have had contact with a INH-resistant case, or who acquired their infection in an area with a high prevalence of resistant organisms, such as Asia, Latin America, or Africa, drug resistance should be suspected and drug sensitivity tests should be performed