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What to do if you get Champix side effects Most mild Champix side effects can be managed at home by: taking the tablets with a full glass of water getting some rest until you feel better drinking plenty of clear fluids to stay hydrated eating smaller, more frequent meals taking over-the-counter painkillers like paracetamol and ibuprofen If you get any of the following serious side effects , you should stop taking varenicline, speak to a doctor, and call 999 in an emergency: seizures stroke heart attack suicidal thoughts psychosis changes in thinking and behaviour severe skin reactions allergic reactions (swelling of the face, mouth, or throat, and difficult breathing and/or swallowing) Champix warnings Champix may not be suitable for everyone