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This design was selected because the estimate of within-arm standard deviation (SD) from the external pilot study had a wide confidence interval and the interim analysis would allow for a more accurate estimation of the SD as a basis for assessing whether the expected effect size could be feasibly demonstrated

[4:37] Chronic caffeine use can result in physical and psychological dependence

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(SNAP) Suspect Flees Wreck Scene, Caught Hiding Behind House The Locust Police Department assisted the NC State Highway Patrol in locating a subject who fled from a wrecked vehicle after attempting to elude a traffic stop