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Contributing Factors Certain factors may increase the risk for ulcers in NSAID users: Being age 65 or older Having a history of peptic ulcers or upper gastrointestinal bleeding Having other serious ailments, such as congestive heart failure Using other medications, such as the anticoagulant warfarin (Coumadin), corticosteroids, or the osteoporosis drug alendronate (Fosamax) Abusing alcohol Being infected with H pylori Other Risk Factors for Ulcers from H pylori or NSAIDs Stress and Psychological Factors Although stress is no longer considered a cause of ulcers, some studies still suggest that stress may predispose a person to ulcers or prevent existing ulcers from healing