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Conclusion The need for further research to develop better methods and research based policies for safe cigarette smoking and workable cessation strategies must be a priority in order to deal with the tobacco epidemic

Landi MT, Dracheva T, Rotunno M, Figueroa JD, Liu H, Dasgupta A, et al

The primary analysis will follow the intention-to-treat principle (ITT) [40] whereby all participants that drop out of the study or are otherwise lost-to-follow-up will be classified as still smoking

IHGE cells in the cell culture plate (100 mm, 3020100, IWAKI), treated with or without CSE for 1 h, were washed with PBS and suspended in 10 mL of ice-cold distilled water for 1 h at 4 C to rupture cells