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It means that cigarette companies must adhere to certain guidelines regarding their marketing materials (such as the type of images they can use).If these rules are violated, Health Canada can take punitive action against companies, such as suspending or canceling advertising contracts

We carried out the integration analysis using the top 30 dimensions from a canonical correlation analysis (CCA) based on SCTransform normalized expression of the top 3000 most informative genes across donor datasets, where informativeness was defined by gene dispersion (i.e., the log of the ratio of expression variance to its mean) across cells, calculated after accounting for its relationship with mean expression (using the SelectIntegrationFeatures function)