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Conclusion four Nicotine as a compound is harmful: While Nicotine in very high doses can be toxic and potentially deadly, in lower doses it is metabolized quickly by the body, with a half-life of around 2 hours, and there is significant research that indicates nicotine has beneficial effects in treating ulcerative colitis, Alzheimer's disease, Parkinson's disease, Tourette syndrome, attention deficit hyperactivity disorder, and obesity. [Source: xPharm: The Comprehensive Pharmacology Reference 2007, Pages 1-8, by Michael D.Meyer]