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It appears that a significant percentage of the population has begun substituting smuggled for legal hand-rolled cigarette tobacco, even though legal hand-rolled cigarette tobacco is typically cheaper than legal cigarettes

Although research activity occurred across 53 foreign (non-US) countries, 97.8% (91) of the grants were awarded to institutions in HICs (primarily the US, Canada, and the UK), with only three grants awarded directly to LMIC institutions in two countries (India and Mexico)

After reviewing a number of cases, the Appellate Body stated, "the 'treatment no less favourable' standard of Article III:4 of the GATT 1994 prohibits WTO members from modifying the conditions of competition in the marketplace to the detriment of the group of imported products vis--vis the group of domestic like products." 75 The Appellate Body elaborated on how its standard should be applied when de facto discrimination is alleged: Accordingly, where the technical regulation at issue does not de jure discriminate against imports, the existence of a detrimental impact on competitive opportunities for the group of imported vis--vis the group of domestic like products is not dispositive of less favourable treatment under Article 2.1