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We found dermal contact with nicotine may impair wound healing, increase susceptibility to skin infections due to a decrease in immune response, and cause oxidative stress in skin cells, Giovanna Pozeulos, recent UC Riverside graduate and study contributor, said in a statement

The 4-methylnitrosamino-1-3-pyridyl-1-butanone (NNK) and N'nitrosonornicotine (NNN) derivatives of nicotine both exhibit oncogenic properties

This can make breathing more difficult and result in chest pain

Instead the evidence consistently finds that e-cigarettes are another tool for stopping smoking and in my view smokers should try vaping and vapers should stop smoking entirely