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Between then and January 2022, MHRA received 257 Yellow Card adverse reaction reports covering 720 adverse reactions.[29] The MHRA assesses all reports received in associated with nicotine-containing e-cigarettes and should any potential safety concerns be identified regulatory action would be taken and communicated as appropriate

For both boys and girls, the amount smoked was inversely related to the level of FEV 1 /FVC (forced vital capacity), as well as to the forced expiratory flow (FEF) [between 25% and 75% of the FVC (FEF 2575 )] (Table 2.8)

doi: 10.1136/hrt.2008.147066

This is a plausible claim backed up by reams of documentation, sufficient to convince even the FDA to authorize IQOS for sale in the United States and allow it to be marketed with claims of reduced exposure to harmful toxicants compared to cigarettes