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Exploratory mixed effects models (see Supplemental Material) were used, where appropriate, to compare urinary concentrations of CBD, 7-OH-CBD or 7-CBD-COOH (I) between routes of administration or (II) oral formulations with the factors of dose condition and time post-administration (baseline and 16 time points) and (III) between fasted states with the factors of dose condition (overnight fasting and standard low-fast breakfast) and time post-administration (baseline and 16 time points)

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Those who insist they are 95% less dangerous are therefore only making fingers-crossed predictions, much in the same way that the scientific colossus Ernst Wynder (who published the first case control study on smoking and lung cancer) did about his hopes for reduced-risk cigarettes