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Abbreviations AHR: Adjusted hazard rate ASH: Action on Smoking and Health AOR: Adjusted odds ratio ARR: Adjusted risk ratio CI: Confidence interval COPD: Chronic obstructive pulmonary disease EC: Electronic cigarette eCO: Expired carbon monoxide eNO: Expired nitric oxide EPA: Environmental Protection Agency HRCT: High-resolution computed tomography NHIS: National Health Interview Survey PATH: Population Assessment of Tobacco and Health PICO: Population, intervention, comparator, outcomes PRISMA: Preferred Reported Items for Systematic Reviews and Meta-Analyses RCT: Randomized controlled trial VERITAS Study: The Vaping Effects: Real-World International Surveillance Study WHO: World Health Organization References National Academies of Sciences E, Medicine (2018) Public health consequences of E-cigarettes

"Oh god, what time is it?" She rolled over and looked at her clock

Special acknowledgment is extended to Mohammed Jafer for his helpful assistance in data analysis and quality assessment