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It has cooling, analgesic, and irritative properties, reflecting its interactions with specific neuronal biological receptors that can modulate pain and communicate to areas of the brain concerned with taste and other sensations

According to the World Health Organization (WHO), over one billion people worldwide are regular tobacco smokers, making cigarettes the most popular way of consuming Nicotine

Yet, cisplatin resistance stems from complex genetic and epigenetic changes occurring in almost every mechanism supporting cell survival, including cell growth-promoting pathways, DNA damage repair, cell-surface binding, and transporters for cisplatin 47

Over years, this increases the risk of cancer even in people who have never smoked. Unlike smoking, where risk depends on consumption, pollution exposure is uniform and unavoidable, making entire urban populations vulnerable