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More important, these increased inflammatory indices and expressions of epithelial and lung p-ERK and p-JNK induced by both types of CS were greatly suppressed to similar levels after treatment with a TRPM8 antagonist, AMTB (Figures 26)

One explanation for this difference may be the short period of usage of vapes, as the sample comprised middle and high school students, which may have led to lower exposure and reduced adverse effects