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In addition to the multivariate analyses above, we also sought to directly contrast the metabolome of Lactobacillus -dominated CST-I/III and the low- Lactobacillus/ diverse anaerobes observed in CST-IV

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Nonetheless, the US Food and Drug Administration (FDA) and state and local governments have increasingly restricted flavors in nicotine or tobacco products, including certain e-cigarette models (e.g., open system e-cigarettes with flavors other than menthol/tobacco/mint)