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Has potent effects on the mammalian colon, inhibiting neurogenic and, at higher concentrations, myogenic contractions, profoundly disrupting gastrointestinal motility. Further, between 50-80% of clozapine-treated patients have unambiguous evidence of CIGH

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states, incentivizing smuggling and illicit activity.[11] After New York, the highest rate of smuggling occurs in California (44.8 percent of consumption smuggled), New Mexico (45.5 percent), Washington (41.5 percent), and Minnesota (34.8 percent)