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This is what is thought to have occurred in previous studies indicating CYP2B6 rs2279343 16 and CHRNA4 rs1044396 15 as possible markers of better responses to bupropion and varenicline: selection bias within the original dataset of 900 patients submitted to smoking cessation treatment between 2007 and 2013

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These findings suggest occupational exposures may confer a slightly higher prostate cancer risk compared to general lifestyle factors such as smoking, emphasizing the need for targeted preventive strategies in occupational settings