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Although synthetic nicotine has been manufactured, it is not commercially viable and the nicotine in electronic cigarette liquid comes from exactly the same source as the nicotine in tobacco it is extracted from plants including the tobacco leaf

Another important therapeutic consideration is the potential for pharmacological overlap or synergy

Since the FDA regulations were signed, if a vape shop mixes or prepares e-liquids or creates or modifies aerosolizing apparatus for direct sale to consumers for use in ENDS, the establishment fits within the definition of tobacco product manufacturer. These tobacco product manufacturers are subject to more stringent regulations than vape shops that only sell pre-fabricated e-liquid solutions

Convenience-store retailers and others who sell tobacco products are cautious on the outlook for the category