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Although 12 of 15 studies in which the effects of smoking cessation on vascular endothelial function was assessed by physiological methods including measurements of FMD and reactive hyperemia index (RHI) showed that smoking cessation improved FMD, RHI or vascular response to vasoactive agents [18, 21, 22, 25,26,27,28,29, 32,33,34,35], three of those 15 studies showed no effects of smoking cessation on FMD or RHI [89,90,91]