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"Further, the selection criteria for randomized trials may limit generalizability to the population." Clinical trials suffer from extreme selection bias

Photo Credit: Sean Pavone / Shutterstock Percentage of adults who smoke: 23.1% Percentage of adults in poor physical health: 16.0% Percentage of adults with COPD: 6.8% Percentage of adults with cancer: 5.3% Percentage of adults who have experienced a stroke: 3.7% Percentage of adults with coronary heart disease: 6.0% Population: 589,067 Photo Credit: Sean Pavone / Shutterstock Percentage of adults who smoke: 24.3% Percentage of adults in poor physical health: 17.4% Percentage of adults with COPD: 9.3% Percentage of adults with cancer: 5.6% Percentage of adults who have experienced a stroke: 4.8% Percentage of adults with coronary heart disease: 7.3% Population: 649,705 Photo Credit: Sean Pavone / Shutterstock Percentage of adults who smoke: 27.8% Percentage of adults in poor physical health: 18.7% Percentage of adults with COPD: 11.1% Percentage of adults with cancer: 5.9% Percentage of adults who have experienced a stroke: 5.6% Percentage of adults with coronary heart disease: 9.0% Population: 378,589 Photo Credit: Sean Pavone / Shutterstock Percentage of adults who smoke: 28.9% Percentage of adults in poor physical health: 20.9% Percentage of adults with COPD: 11.2% Percentage of adults with cancer: 6.0% Percentage of adults who have experienced a stroke: 6.2% Percentage of adults with coronary heart disease: 8.9% Population: 665,369 The data used in this analysis is from the CDCs Behavioral Risk Factor Surveillance System (BRFSS)

A lighter smoker may look to use one of our lower strengths while a heavier smoker will want to choose a higher nicotine strength

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