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The age-standardized mortality rate for smoking-related prostate cancer globally decreased from 0.279 (95% UI: 0.1300.454) in 1990 to 0.155 (95% UI: 0.0700.258) in 2021, with an average annual decline of 2.19% (95% UI: -2.29 -2.09)

Delayed motor development, usually associated with primary hypotonia (Additional Table 1), was present in 10.7% of patients without any significant variance between sex and age categories

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