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[51] isolated bronchial tissue from patients with and without COPD, isolated and cultured goblet cells and promoted their differentiation and found that SAM-pointed domain-containing ETS transcription factor (SPDEF) and forkhead box protein A2 (FOXA2) had abnormal DNA methylation during goblet cell differentiation

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Environ Chem Lett 22:12571273

Since they are made from tobacco leaves that have already been cut and processed by manufacturers, why is chewing tobacco abrasive enough to make small cuts in your mouth