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Keywords , biomarkers of compliance , biochemical verification , cutoff value , detection period , tobacco harm reduction 0 1 INTRODUCTION Cigarette smoking is a risk factor of numerous human disorders and a leading cause of many diseases, including cardiovascular disorders, multiple cancers and chronic obstructive pulmonary disease (COPD)

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For example, esters cause a lot of fruity smells, and linear-terpenes produce a woody or sweet smell

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