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A panel of 20 experts with professional experience with substance use issues from across Canada were asked to evaluate 16 different drugs on 10 dimensions of harm to consumers, as well as six dimensions of harm to others, scoring each on a scale of 0 to 100

Potential mechanisms include altered neurochemical pathways [9], systemic inflammation [10], and disrupted stress regulation [11]

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The nicotine dose should then be gradually reduced, by decreasing the total number of tablets used per day. - Nicorette Microtab Lozenge Footnote 5: The SmPC documents (Summary of Product Characteristics) and dosage timelines for Nicorette and Nicotinell patches can be found at the links below: Footnote 6: You may still have the urge to smoke or feel a bit restless, irritable, frustrated or tired