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It laid bare the deceptions practised by the industry over decades and ultimately led to the Master Settlement Agreement.[25] The litigation and close scrutiny the industry was placed under probably accounts for the low-key launch of Philip Morris heated tobacco product Accord in 1997

1 Smoke Sensation Some individuals smoke herbal cigarettes for the ritualistic and sensory aspects of smoking without the addictive properties of nicotine

Evidence suggests multiple interrelated pathways of liver injury: Nicotine-induced injury : Nicotine is metabolized in the liver via CYP2A6, where it activates 7-nicotinic acetylcholine receptors (7-nAChR), leading to oxidative stress, mitochondrial dysfunction, and pro-fibrotic signaling [36, 125, 126]

Laryngitis is swelling and redness of the voice box, or larynx