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Smoking-induced microbial dysbiosis impacts multiple anatomical sites, including the oral cavity, respiratory tract, and gastrointestinal system, driving disease progression through mechanisms such as immune modulation, chronic inflammation, and metabolic dysregulation

At present, endothelial cell dysfunction is the earliest detectable change in the development of an atherosclerotic lesion, which may contribute to a series of CVDs including vascular inflammation, hypertension and cardiomyopathy [105]

Regional trends, regulations, and brand innovation all influence which flavours become popular over time

rustica) and the cured leaf that is used, usually after aging and processing in various ways, for smoking, chewing, snuffing, and extraction of nicotine