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Irsay, who struggled with addiction years earlier, which led to a 2014 arrest for drunk driving and drug possession, died peacefully in his sleep last May at age 65, his family said in a statement at the time

Van der Toorn M, Slebos D-J, De Bruin HG, Leuvenink HG, Bakker SJL, Gans ROB, et al: Cigarette smoke-induced blockade of the mitochondrial respiratory chain switches lung epithelial cell apoptosis into necrosis

Settlements have been reached with 47 states and territories and 5,000 individuals and local governments, costing Juul nearly $3 billion so far