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Another study on human organotypic oral epithelial cultures showed that IQOS, compared to CS, yielded less cytotoxicity (significant after 48 h post-exposure), secretion of proinflammatory mediators, and gene expression perturbations related to apoptosis, necroptosis, senescence, xenobiotic metabolism, and oxidative stress 58

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It has also shown to harm womens fertility and cause menstrual disorders and affect sperm motility (meaning movement or mobility) in men

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