CA-Cy3 protac 15 SMILES Cl

15 SMILES Cl

enabling efficient and selective conjugation of the payload to the linker

1038/nature13527

612 SMILES: OC(=O)C1=CC=C(C(=C1)C([O-])=O)C1=C2C=C3CCC[N+]4=C3C(CCC4)=C2OC2=C3CCCN4CCCC(C=C12)=C34

CA-Cy3 protac 15 SMILES ClHaloTag is a self labeling protein tag engineered from the haloalkane dehalogenase DhaA, originally isolated from Rhodococcus rhodochrous. Its active site binds chloroalkane (CA)substrates, forming an irreversible covalent bond. This stable linkage between the HaloTag protein and its ligand enables rapid and efficient isolation and purification of tagged proteins. CA Cy3 is a HaloTag ligand with Cyanine3 dye. Cy3 (Cyanine 3, 550Ex 570Em) is known for