Fmoc-Val-Cit-PAB(m-PEG8) 4' 866 SMILES CC(C)(C)OC(=O)CN1CCN(CC(=O)NCCOCCO)CCN(CC(=O)OC(C)(C)C)CCN(CC(=O)OC(C)(C)C)CC1 Purity (HPLC)

866 SMILES CC(C)(C)OC(=O)CN1CCN(CC(=O)NCCOCCO)CCN(CC(=O)OC(C)(C)C)CCN(CC(=O)OC(C)(C)C)CC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Product Name Thalidomide-O-acetamido-propargyl Synonyms Thalidomide-4'-O-acetamido-propargyl CAS Number n/a Related CAS Molecular Formula C18H15N3O6 Molecular Weight 369

1 Purity (HPLC) >= 95% Physical Appearance Yellow Solid Optical Properties Abs/Em Maxima: 496/516 nm Solubility DMSO

& Broichhagen

Fmoc-Val-Cit-PAB(m-PEG8) 4' 866 SMILES CC(C)(C)OC(=O)CN1CCN(CC(=O)NCCOCCO)CCN(CC(=O)OC(C)(C)C)CCN(CC(=O)OC(C)(C)C)CC1 Purity (HPLC)SOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate solubilizing moietiessuch as PEG, amine containing groups, or polysarcosine (PSAR), to enhance aqueous solubility. Solubility and physicochemical properties can be finely tuned