DBCO-Lys(m-PEG4)-Val-Cit-PAB(m-PEG8)-Exatecan dbco-lys-m-PEG4 12 SMILES: [2H]C([2H])([2H])OC1=CC=C(C=C1)B1OC(C)(C)C(C)(C)O1 Isotopic Enrichment:

12 SMILES: [2H]C([2H])([2H])OC1=CC=C(C=C1)B1OC(C)(C)C(C)(C)O1 Isotopic Enrichment: 98 atom % D Purity (HPLC): ≥ 95% Shipping Conditions: room temperature Storage Conditions: Refrigerated Regulatory Statement: For Research Use Only

Through the SPAAC (Strain-Promoted Azide-Alkyne Cycloaddition) reaction

92 SMILES CC1=C(SC=N1)C1=CC=C(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCOCCOCCOCCOCCO)C(C)(C)C)C=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

5(6)-TAMRA cadaverine is a useful reagent for modifying carboxy groups via EDC-mediated reactions

DBCO-Lys(m-PEG4)-Val-Cit-PAB(m-PEG8)-Exatecan dbco-lys-m-PEG4 12 SMILES: [2H]C([2H])([2H])OC1=CC=C(C=C1)B1OC(C)(C)C(C)(C)O1 Isotopic Enrichment:SOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a DBCO Lys(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. DBCO is a strained alkyne commonly used in copper free click chemistry, specifically in the strain promoted azide alkyne cycloaddition (SPAAC) reaction. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further