MC-Val-Cit-PAB(m-PEG8)-Exatecan m-peg4 Product Name Thalidomide-5'-propargyl-PEG3-OH Synonyms CAS

Product Name Thalidomide-5'-propargyl-PEG3-OH Synonyms CAS Number n/a Related CAS Molecular Formula C22H24N2O8 Molecular Weight 444

7 Purity (HPLC) >= 95% Solubility DMSO

74 SMILES CC1=C(SC=N1)C1=CC=C(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCOCCOCCOCCOCCBr)C(C)(C)C)C=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

1038/nature13527

MC-Val-Cit-PAB(m-PEG8)-Exatecan m-peg4 Product Name Thalidomide-5'-propargyl-PEG3-OH Synonyms CASSOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage by stabilizing the topoisomerase IDNA complex, resulting in cell cycle arrest and apoptosis. Derived from established ADC linker architectures,