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Abbreviations The following abbreviations are used in this manuscript: Author Contributions Conceptualization, G.S

Summary Ensuring that you have enough vitamin B12 is important for brain function and mental, bone and eye health

Understanding how liver pathology affects B12 metabolism helps clarify why levels may become elevated in certain circumstances

(Qiu et al., 2023) reported low levels of NAD + in the aorta from hypertensive patients showing that supplementation with NAD + precursors effectively lowered blood pressure and improved impaired vascular function in both hypertensive patients and mice