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Edited by Marmot M, Wilkinson RG

[DOI] [PubMed] [Google Scholar] 163.Tinkle BT, Bird HA, Grahame R, Lavallee M, Levy HP, Sillence D

Hutt and colleagues (2005) developed a model that achieved a 10-fold increase in hyperplastic lesions, a 4.6-fold increase in adenomas and papilloma, a 7.25-fold increase in adenocarcinomas, and a 5-fold increase in metastatic pulmonary adenocarcinomas in mice with lifetime whole-body exposure to cigarette smoke compared with lesions in air-only sham controls

Answer this question to get a guide for the nicotine strength you should be going for: Heavy smokers You are likely going to need the strongest legal strength available in the UK, 20mg/ml (or 2%) in order to satisfy your nicotine cravings