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On the other hand, overactivation of terminal respiratory chain components (such as COX4I2 and ATP5F1B) may exacerbate metabolic imbalances and cellular stress responses under diabetic and DKA pathological conditions, potentially increasing DKA risk

Consistent with its significance, LSD1 deficiency disrupts early embryogenesis, particularly during gastrulation, highlighting its essential role in development 161

Since mitochondria are the primary source of ROS, we observed through MitoSOX Red staining the mitochondrial ROS of PANC-1 cells, which were the cells with the most marked increase in ROS level (Fig

10.1007/s00068-007-7152-z 16 El-HoranyH