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[16] History, society and culture [edit] "Aphthous affectations" and "aphthous ulcerations" of the mouth are mentioned several times in the treatise "Of the Epidemics" (part of the Hippocratic corpus, in the 4th century BCE), [25] although it seems likely that this was oral ulceration as a manifestation of some infectious disease, since they are described as occurring in epidemic-like patterns, with concurrent symptoms such as fever

Humphrey Bogart's Constant Smoking Served A Practical Purpose Humphrey Bogart is practically impossible to recognize without a cigarette hanging from his lip

The process behind this phenomenon is that nicotine stimulates the adrenal glands, which release epinephrine and increase blood pressure

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