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Withdrawal from smokeless tobacco can cause intense cravings, anger, and depression

Its interesting from a scientific standpoint, but boy does it complicate the public health messaging. Prior to the CANDIDE study, Springer and his UCSF research group had done many studies in rats, which have similar cardiovascular responses to tobacco smoke as humans do, and which can be studied under tightly controlled experimental conditions

People who dont plan to quit smoking may not realize the benefits that can come from giving up cigarettes even after many years of smoking, and are less likely than other smokers to have tried e-cigarettes, the authors noted