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In essence, bremelanotide can fill a gap for those who cannot use or tolerate the first-line oral medications

Fluctuations in intraocular pressure (IOP), insufficient blood supply to the optic nerve, malnutrition, trauma, hypoxia-induced inflammatory responses, and degeneration of RGCs are the basic factors for its onset (123), among which the increase in pathological intraocular pressure (ph-IOP) and the death of RGCs are the key factors (124)

The product is available in three graduated strengths-Strong (0.045 % tretinoin / 4 % azelaic acid / 4 % niacinamide), Mild (0.03 % / 4 % / 4 %), and Sensitive (0.015 % / 4 % / 4 %)-each filled in 30 g air-tight pumps to preserve potency and minimize oxidation

After incubation in the dark for 20 min with gentle shaking to ensure effective probe uptake, the samples were incubated at 37C