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In the IBD inflammatory microenvironment, macrophages polarize to the M1 phenotype, characterized by enhanced glycolysis, accompanied by a reduction in pyruvate dehydrogenase (PDH) activity, leading to lactate accumulation and a shift in energy supply mechanisms

Results L-Theanine improves skin appearance in aged rats After eight weeks of D-galactose administration, rats in the model group displayed evident signs of skin aging, characterized by deep static wrinkles, erythema, hair thinning, and loss of coat luster

Clinical studies demonstrate BDNF dysregulation in ASD patients, with preclinical models showing hippocampal neuroprotection upon BDNF administration [27, 28]