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Developed by Eli Lilly and Company, orforglipron represents a fundamental departure from every GLP-1 receptor agonist currently on the market: it is not a peptide, it does not require injection, it does not need an absorption enhancer like SNAC, and it imposes no fasting or water restrictions on patients

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For patients at high risk of NAFLD, this study might indicate that the intake of vitamin B12 may be restricted because it might elevate the serum vitamin B12 concentrations, and then increase the risk of NAFLD

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