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Moreover, the role of necroptosis in PD has been witnessed in MPTP (1methyl4phenyl1,2,3,6tetrahydropyridine) and 6-OHDA (6-hydroxy-dopamine)-induced PD in animal models [55]

Unlike GPx1GPx4, GPx5 does not contain selenocysteine but contains cysteine residues in the active site, and GPx5 does not exhibit typical dismutation activity toward substrates such as H 2 O 2 (Taylor et al