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Even when intrinsic factor is not present to aid in the absorption of vitamin B 12 (pernicious anemia) or in other diseases that affect the usual absorption sites in the terminal ileum, oral therapy remains effective

Also, one less metabolic step is needed for the conversion of hydroxocobalamin than cyanocobalamin

The main difference from proteins lies in their length and structure: peptides generally have molecular weights below 5000 Da and often lack stable three-dimensional structures, whilst proteins contain more than 100 amino acids, exceed 5000 Da in molecular weight, and fold into complex three-dimensional conformations with multiple functional domains