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Furthermore, Germain et al

Nitric oxide activates guanylate cyclase and increases guanosine 3:5-cyclic monophosphate levels in various tissue preparations

Mechanism of regulation of proportions of dephosphorylated and phosphorylated enzyme by oxidation of fatty acids and ketone bodies and of effects of diabetes: Role of coenzyme A, acetyl-coenzyme A and reduced and oxidized nicotinamide-adenine dinucleotide

These reactive aldehydes can attack additional intracellular targets, including proteins and DNA, extending initial membrane damage to other macromolecules and cellular regions