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Long-term nicotine use affects digestive health through multiple mechanisms: Altering gut microbiome composition and diversity Changing blood flow patterns to digestive organs Modifying nervous system signaling pathways Creating dependency for normal bowel function For people with Crohn's disease, continuing nicotine use can be particularly harmful

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Moreover, e-cigarettes are marketed as a harm-reduced alternative to combustible cigarettes 5 , and to support cigarette smoking cessation, despite mixed evidence of their effects for cigarette cessation 6,7